Effect of Antibiotic Class on Stroke Outcome

In rats but it probably does mean that if you get an infection post-stroke you'll have to direct your doctor to give you the correct antibiotic. Once again, I bet this will not be followed up in human testing for 50 years because we have NO one running a stroke strategy. No one seems to give a shit about the trillions upon trillions of neurons dying every single minute worldwide.  We're flushing vast amounts of intelligence down the tube because the intelligence in our stroke associations is non-existent. 
http://www.ncbi.nlm.nih.gov/pubmed/26138122

Zierath D¹, Kunze A¹, Fecteau L¹, Becker K².

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Abstract

BACKGROUND AND PURPOSE:

Infections are common after stroke and associated with worse outcome. Clinical trials evaluating the benefit of prophylactic antibiotics have produced mixed results. This study explores the possibility that antibiotics of different classes may differentially affect stroke outcome.

METHODS:

Lewis rats were subjected to transient cerebral ischemia (2 hours) and survived for 1 month. The day after stroke they were randomized to therapy with ceftiofur (a β-lactam antibiotic), enrofloxacin (a fluoroquinolone antibiotic), or vehicle (as controls) and underwent the equivalent of 7 days of treatment. Behavioral tests were performed weekly until euthanization. In a subset of animals, histology was done.

RESULTS:

There were no differences in outcomes at 24 hours or 1 week after stroke among the different groups. At 1 month after stroke, however, performance on the rotarod was worse in enrofloxacin-treated animals when compared with control animals.

CONCLUSIONS:

Independent of infection, the antibiotic enrofloxacin was associated with worse stroke outcome. These data echo the clinical observations to date and suggest that the secondary effects of antibiotics on stroke outcome should be considered when treating infection in subjects with stroke. The mechanism by which this antibiotic affects outcome needs to be elucidated.