Interplay between nitric oxide and brain-derived neurotrophic factor in neuronal plasticity

So go ask your doctor EXACTLY what you should be doing about getting nitric oxide for your recovery. BDNF is important, does your doctor know anything about its use for recovery? I have 50 posts on nitric oxide  and 78 posts on BDNF if you need to train your doctor on the subjects.
http://europepmc.org/abstract/med/26350341

(PMID:26350341)

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Biojone C, Casarotto PC, Joca SR, Castrén E

Neuroscience Center, University of Helsinki, Viikinkaari 4, 00790, Helsinki, Finland. caroline.biojone@helsinki.fi.

CNS & Neurological Disorders Drug Targets [2015]

Type: Journal Article

Abstract

Highlight Terms Gene Ontology(1) Genes/Proteins(5) Species(1) Chemicals(2)

Nitric oxide is a gaseous neuromodulator that displays a core role in several neuronal processes. Beyond regulating the release of neurotransmitters, nitric oxide also plays a role in cell differentiation and maturation in the central nervous system. Although the mode of action of nitric oxide is not fully understood, it involves the activation of soluble guanylate cyclase as well as the nitration and S-nitrosylation of specific amino acid residues in other proteins. Brain-derived neurotrophic factor is a member of neurotrophic factor family and, acting through its receptor tropomyosin-related kinase B, increases the production of nitric oxide, modulates neuronal differentiation and survival, and plays a crucial role in synaptic plasticity, such as long-term potentiation. Furthermore, nitric oxide is an important regulator of the production of these factors. The aim of the present review is to present a condensed view of the evidence related to the interaction between nitric oxide and brain-derived neurotrophic factor. Additionally, we conducted bioinformatics analysis based on the amino acid sequences of brain-derived neurotrophic factor and tropomyosin-related kinase receptors, and proposed that nitric oxide might nitrate/S-nitrosylate these proteins. Thus, we suggest a putative direct mode of action between these molecules to be further explored.