Friday, September 11, 2015

Protein synthesis in regenerating spinal cord axons

If we had any stroke strategist in the stroke associations or anywhere they would be looking at how to repurpose this for stroke. But we have no one and are screwed in our stroke rehab.
http://nro.sagepub.com/content/21/5/448?etoc
A Kalinski, R Sachdeva, C Gomes, SJ Lee, Z Shah, JD Houle , and others. 2015. mRNAs and protein synthetic machinery localize into regenerating spinal cord axons when they are provided a substrate that supports growth. J Neurosci 35(28):1035770.
RB Perry, M Fainzilber . 2014. Local translation in neuronal processes-in vivo tests of a “heretical hypothesis”. Dev Neurobiol 74(3):2107.
While it is well established that ribosomes and mRNAs provide a substrate for protein synthesis within the cell bodies of neurons, there has been debate about whether this biosynthetic machinery is present within the axons of mature neurons. An increasing number of studies have suggested that growing axons exhibit the capacity for protein synthesis, and there is evidence that proteins are synthesized locally within regenerating PNS axons where they provide a substrate for retrograde signaling and act locally as axons extend (Perry and Fainzilber 2014). In contrast, less attention has been given to the question of whether mature CNS …

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