The Madison Memory Study Final Report

The book written about it here:
http://astore.amazon.com/alzheimerswee-20/detail/1467523690

A short writeup here:
The Madison Memory Study (MMS) was a three month long double-blinded, placebo-controlled study which assessed the effect of apoaequorin on cognitive function and other quality of life measures in adults over 40 years old with mild memory concerns associated with aging.*
The study protocol builds upon the evidence in previous pilot studies which demonstrated apoaequorin improved memory as measured by participant reported outcomes. The technology which MMS uses to measure cognitive changes in participants is a computer based assessment using software developed by CogState Ltd., a global provider of cognitive testing products and services. Participants were tested at baseline and then re-assessed four more times during the three month period.

The nine page research paper here:

The Effects of the Calcium Binding Protein Apoaequorin on Memory and Cognitive Functioning in Older Adults

Background

We report here on a double-blind, placebo controlled study designed to assess the effect of an apoaequorin dietary supplement, compared to placebo, on specific areas of cognitive functioning using quantitative, computerized assessments. In recent open label and double-blind, placebo controlled trials, older adults taking an apoaequorin dietary supplement reported improvements in cognitive functioning. Apoaequorin is a protein originally isolated from the jellyfish Aequorea victoria.

Methods

 

A total of 218 adults, aged 40 to 91 years, who had self-reported mild memory problems were randomly assigned to receive a 90 day supply of either apoaequorin 10mg or a matched placebo. Participants were tested at 

predetermined time points using computer-based assessments from CogState Ltd (www.cancog.com). Changes on specific assessments of cognitive function were measured at various time points during the study.

Results

 The apoaequorin arm showed a significant improvement in scores of executive functioning on the Groton Maze Learning task over the 90 day study period. In measures of learning, study participants given apoaequorin demonstrated significantly improved recall performance at Day 90 compared to Baseline. In an assessment of short-term memory and learning, the Prevagen arm saw significant improvement at Day 90 compared to baseline in the One Card Learning task. The Prevagen group also improved their ability to recall shopping list items from a previously presented list in the International Shopping List test. Apoaequorin was very well tolerated in this study.

 

Conclusion

These results indicated a strong relationship between apoaequorin and improvements on several quantitative measures of cognitive function. Apoaequorin has been shown to be a well-tolerated and effective dietary supplement for use by adults as they age. These results suggest a supportive role for apoaequorin in improving memory for people experiencing normal age-related memory problems.

 

More at link.