Saturday, January 16, 2016

Antidepressant use is associated with an increased risk of developing microbleeds

Well shit, your doctor is going to have to analyze the benefits of antidepressant use in helping your recovery vs.  these microbleeds. Does your doctor even know about the positives of antidepressants?
You'll have to ask your doctor why antidepressants were selected as the cause of the microbleeds rather than aspirin or warfarin use or something else entirely. This would seem to be research that was intent on proving something rather than finding the real reason.
http://www.mdlinx.com/internal-medicine/medical-news-article/2016/01/11/antidepressive-agents-cerebral-microbleeds-cerebral-small/6469902/?news_id=881&newsdt=011616&subspec_id=488&utm_source=WeeklyNL&utm_medium=newsletter&utm_content=Weeks-Best-Article&utm_campaign=article-section&category=latest-weekly
Stroke, 01/11/2016
In this study, the authors investigated longitudinally whether antidepressant use is associated with an increased risk of new subclinical cerebral microbleeds. Antidepressant use was associated with an increased risk of developing microbleeds. The results may support findings from previous clinical studies about increased intracranial and extracranial bleeding risk in antidepressant users.

Methods

  • In total, 2559 participants aged ≥45 years of the population-based Rotterdam Study, all without microbleeds at baseline, underwent baseline and repeat brain magnetic resonance imaging between 2005 and 2013 (mean time interval, 3.9 years; SD, 0.5) to determine the incidence of microbleeds.
  • Antidepressant use (yes versus no) was assessed between baseline and follow-up scan.
  • In additional analyses, antidepressants were classified as low, intermediate, or high affinity for the serotonin transporter, and alternatively as selective serotonin reuptake inhibitors or non-selective serotonin reuptake inhibitors.
  • The authors used multivariable logistic regression models to investigate the association of antidepressants with incident microbleeds.

Results

  • Antidepressant use was associated with a higher cerebral microbleed incidence (odds ratio, 2.22; 95% confidence interval, 1.31-3.76) than nonuse.
  • When stratified by affinity for the serotonin transporter, intermediate serotonin affinity antidepressant use was associated with an increased risk of developing microbleeds (odds ratio, 3.07; 95% confidence interval, 1.53-6.17).
  • Finally, selective serotonin reuptake inhibitor and non-selective serotonin reuptake inhibitor use were both associated with increased microbleed incidence.

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