Use the labels in the right column to find what you want. Or you can go thru them one by one, there are only 29,395 posts. Searching is done in the search box in upper left corner. I blog on anything to do with stroke. DO NOT DO ANYTHING SUGGESTED HERE AS I AM NOT MEDICALLY TRAINED, YOUR DOCTOR IS, LISTEN TO THEM. BUT I BET THEY DON'T KNOW HOW TO GET YOU 100% RECOVERED. I DON'T EITHER BUT HAVE PLENTY OF QUESTIONS FOR YOUR DOCTOR TO ANSWER.
Sunday, January 17, 2016
Neural stem cells sustain natural killer cells that dictate recovery from brain inflammation
How much brain inflammation is there post stroke? How do we harness this process? We'll never know because we have NO stroke leadership or strategy.
Recovery from organ-specific autoimmune diseases largely
relies on the mobilization of endogenous repair mechanisms and local
factors that control them. Natural killer (NK) cells are swiftly
mobilized to organs targeted by autoimmunity and typically undergo
numerical contraction when inflammation wanes. We report the unexpected
finding that NK cells are retained in the brain subventricular zone
(SVZ) during the chronic phase of multiple sclerosis in humans and its
animal model in mice. These NK cells were found preferentially in close
proximity to SVZ neural stem cells (NSCs) that produce interleukin-15
and sustain functionally competent NK cells. Moreover, NK cells limited
the reparative capacity of NSCs following brain inflammation. These
findings reveal that reciprocal interactions between NSCs and NK cells
regulate neurorepair.
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