Tuesday, March 8, 2016

Chronic Stress Causes Brain Inflammation, Memory Loss

What is your doctors answer to brain inflammation?
Tumeric? How much? Which derivative?
Nanoparticles? How much? Where delivered?
tristetraprolin? How much?
Natural killer (NK) cells? How much? How delivered?
Gout drug - colchicine? How much? How delivered?
CSF1R protein? How much? How delivered?
Puerarin? How much? How delivered?
Resveratrol from red wine? How much? How delivered?
How is your doctor handling your stress from not getting any stroke protocols to get you to 100% recovery?

http://www.biosciencetechnology.com/news/2016/03/chronic-stress-causes-brain-inflammation-memory-loss?
A new study suggests that long-term stress can hurt short-term memory, in part due to inflammation brought on by an immune response.
Researchers from Ohio State University performed experiments where mice were exposed to repeated social defeat by exposure to an aggressive, larger, alpha mouse.  The mice that were under chronic stress, had difficulty remembering where the escape hole was in a maze they had previously mastered before the stressful period.
The findings were published in The Journal of Neuroscience.
“The stressed mice didn’t recall it. The mice that weren’t stressed really remembered it,” lead researcher Johnathan Godbout, associate professor of neuroscience at Ohio State, said in statement.
The researchers noted that this kind of stress isn’t the once-in-a-while, acute stress someone might feel before a big meeting or presentation, but prolonged, continued stress.
The mice also displayed depressive-like behavior through social avoidance that continued after four weeks of observation.
Brain changes were also observed in the stressed mice, including inflammation associated with the presence of immune cells, known as macrophages, in the brain.  The researchers also recorded shortfalls in the development of new neurons at 10 days and 28 days after the chronic stress ended.
John Sheridan, associate director of Ohio State’s Institute for Behavioral Medicine said in a statement that there might be ways to interrupt the inflammation that occurs in the brain.
When the mice were given a chemical that inhibited inflammation, both memory loss and the inflammatory macrophages disappeared, leading researchers to conclude that post-stress memory deficits is directly tied to inflammation and the immune system. The depressive symptoms and the brain-cell problem did not go away.
“Stress releases immune cells from the bone marrow and those cells can traffic to brain areas associated with neuronal activation in response to stress,” Sheridan said. “They’re being called to the brain, to the center of memory.”
The team aims to understand the underpinnings of stress and responses that could one day lead to treatments for people that suffer from anxiety, depression, or post-traumatic stress disorder.
New information from this study could lead to immune-based treatments, Godbout said.

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