Microgliosis in the Injured Brain Infiltrating Cells and Reactive Microglia Both Play a Role

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microgliosis

accumulation of microglial cells as a reaction to injury to the parenchyma of the central nervous system, a characteristic of nonsuppurative encephalomyelitis.

Microgliosis in the Injured Brain Infiltrating Cells and Reactive Microglia Both Play a Role

1. Ting Li1
2. Shengxiang Zhang1⇑

1. ¹Gansu Key Laboratory of Biomonitoring and Bioremediation for Environmental Pollution, School of Life Sciences, Lanzhou University, Lanzhou, China

1. Shengxiang Zhang, School of Life Sciences, Lanzhou University, No. 222 South Tianshui Road, Lanzhou, Gansu 730000, China. Email: sxzhang@lzu.edu.cn

Abstract

Microgliosis is an intense reaction of CNS microglia to pathogenic insults. One of the characteristic features of microgliosis is an increase in the number of activated microglia at the site of lesion. Ontogenically, microglia are considered to be of mesodermal lineage in the adult CNS, but the origin of the accumulated microglia in pathological conditions remains controversial. Some studies indicate that circulating cells from the bloodstream can infiltrate the CNS and contribute to microglial pool, but some studies suggest that local expansion of reactive microglia is the sole source for parenchymal microglia. Recent data suggest that latent progenitors may also exist in the CNS. Available evidence suggests that multiple sources of microglia may exist under various neurological conditions. In this review, we compare the prevalent views and supporting evidence from different experimental models and provide an overview on the origins of microgliosis.