Long-term association between the dietary inflammatory index and cognitive functioning: findings from the SU.VI.MAX study.

If your doctor, hospital and nutritionist were ANY GOOD AT ALL, they would be creating a stroke diet protocol with anti-inflammatory properties to make sure you had the best chance of cognitive recovery. But you don't, you are once again fucking screwed because no one follows research and implements the findings to help survivors. Some day a medical person is going to say they follow and implement research. I will gladly write up such a person but so far no one seems to fit the bill.

Long-term association between the dietary inflammatory index and cognitive functioning: findings from the SU.VI.MAX study.

Kesse-Guyot E¹, Assmann KE², Andreeva VA², Touvier M², Neufcourt L², Shivappa N^3,4,5, Hébert JR^3,4,5, Wirth MD^3,4,5, Hercberg S^2,6, Galan P², Julia C^2,6.

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Abstract

PURPOSE:

Inflammation is a ubiquitous underlying mechanism of the links between diet and cognitive functioning. No study has yet evaluated the overall inflammatory potential of the diet, using the dietary inflammatory index (DII), in relation to cognitive functioning. In a French cohort of middle-aged adults, we evaluated the association between the DII, assessed in midlife, and cognitive performance evaluated 13 years later.

METHODS:

The DII is a literature-derived dietary index developed to determine the inflammatory potential of diet. The DII was estimated at baseline (1994-1996) among 3080 subjects of the SU.VI.MAX (supplementation with antioxidant vitamins and minerals) cohort. Cognitive performance was assessed in 2007-2009 via a battery of standardized neuropsychological tests. Principal component analysis was performed to extract a summary score of cognitive performance. Multivariable-adjusted linear regression analyses were performed to provide regression coefficients and 95 % confidence intervals (95 % CI).

RESULTS:

In a multivariate model, a strong inverse association was observed between a higher DII (reflecting a more inflammatory diet) and overall cognitive functioning (mean difference Q4 vs. Q1 = -1.76; 95 % CI = -2.81, -0.72, P for trend =0.002). With regard to specific cognitive domains, similar associations were observed with scores reflecting verbal memory, but not executive functioning.

CONCLUSION:

This study suggests that a pro-inflammatory diet at midlife might be associated with subsequent lower cognitive functioning. A diet exhibiting anti-inflammatory properties may help to maintain cognitive health during aging.

CLINICAL TRIAL REGISTRATION:

Clinicaltrials.gov (number NCT00272428).