Adult human dental pulp stem cells promote blood–brain barrier permeability through vascular endothelial growth factor-a expression

Now all we have to do if find an intervention that promotes brain recovery that needs to get thru the blood brain barrier. That a job for 'super stroke leader'. 

Adult human dental pulp stem cells promote blood–brain barrier permeability through vascular endothelial growth factor-a expression

1. Joshua N Winderlich1,2
2. Karlea L Kremer1,2
3. Simon A Koblar1,2,3⇑

1. ¹Stroke Research Programme, School of Medicine, University of Adelaide, Adelaide, Australia
2. ²Centre for Stem Cell Research, Robinson Institute, Adelaide, Australia
3. ³Department of Neurology, Queen Elizabeth Hospital, Woodville, Australia

1. Simon A Koblar, School of Medicine, University of Adelaide, Adelaide, SA 5005, Australia. Email: simon.koblar@adelaide.edu.au

Abstract

Stem cell therapy is a promising new treatment option for stroke. Intravascular administration of stem cells is a valid approach as stem cells have been shown to transmigrate the blood–brain barrier. The mechanism that causes this effect has not yet been elucidated. We hypothesized that stem cells would mediate localized discontinuities in the blood–brain barrier, which would allow passage into the brain parenchyma. Here, we demonstrate that adult human dental pulp stem cells express a soluble factor that increases permeability across an in vitro model of the blood–brain barrier. This effect was shown to be the result of vascular endothelial growth factor-a. The effect could be amplified by exposing dental pulp stem cell to stromal-derived factor 1, which stimulates vascular endothelial growth factor-a expression. These findings support the use of dental pulp stem cell in therapy for stroke.(No, it doesn't, getting thru the barrier is not a therapy in itself)