Pericyte-targeting drug delivery and tissue engineering

How is your doctor going to use this in collaboration with researchers to solve  Capillaries that don't open due to pericytes in the neuronal cascade of death? I bet nothing will happen, your doctor won't step up to the plate because they don't have the correct goals and objectives to actually solve all the problems in stroke. Their goal is to bring in money for the stroke department, not to solve your stroke problems. You should be able to figure out why the signaling doesn't open the capillaries.
https://www.dovepress.com/articles.php?article_id=2716

Authors Kang E, Shin JW
Received 28 January 2016
Accepted for publication 2 April 2016
Published 27 May 2016 Volume 2016:11 Pages 2397—2406
DOI https://dx.doi.org/10.2147/IJN.S105274
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Lakshmi Kiran Chelluri
Peer reviewer comments 3
Editor who approved publication: Dr Thomas Webster

Eunah Kang,¹ Jong Wook Shin<sup>2

1</sup>School of Chemical Engineering and Material Science, ²Division of Allergic and Pulmonary Medicine, Department of Internal Medicine, College of Medicine, Chung-Ang University, Dongjak-Gu, Seoul, South Korea

Abstract: Pericytes are contractile mural cells that wrap around the endothelial cells of capillaries and venules. Depending on the triggers by cellular signals, pericytes have specific functionality in tumor microenvironments, properties of potent stem cells, and plasticity in cellular pathology. These features of pericytes can be activated for the promotion or reduction of angiogenesis. Frontier studies have exploited pericyte-targeting drug delivery, using pericyte-specific peptides, small molecules, and DNA in tumor therapy. Moreover, the communication between pericytes and endothelial cells has been applied to the induction of vessel neoformation in tissue engineering. Pericytes may prove to be a novel target for tumor therapy and tissue engineering. The present paper specifically reviews pericyte-specific drug delivery and tissue engineering, allowing insight into the emerging research targeting pericytes.