Saturday, June 18, 2016

Effects of cilostazol on cognition and regional cerebral blood flow in patients with Alzheimer's disease and cerebrovascular disease: A pilot study

Since your doctor should be concerned about your chances of getting dementia/Alzheimers maybe this can be added to your stroke protocol against dementia. But I almost guarantee that your doctor knows nothing about preventing dementia or even that it is likely you will get it.










Good luck, because you will need it.
Your 33% dementia chance post-stroke from an Australian study?   May 2012.
2. Then this study came out and seems to have a range from 17-66%. December 2013.
3. A 20% chance in this research.   July 2013.
Is your doctor even testing you for MCI post-stroke?
http://onlinelibrary.wiley.com/doi/10.1111/j.1447-0594.2012.00866.x/abstract;jsessionid=3065AD84D5893717785970A20BB2DAD8.f02t02?userIsAuthenticated=false&deniedAccessCustomisedMessage=
  1. Hirofumi Sakurai*,
  2. Haruo Hanyu,
  3. Tomohiko Sato,
  4. Kazumasa Kume,
  5. Kentaro Hirao,
  6. Hidekazu Kanetaka and
  7. Toshihiko Iwamoto
Version of Record online: 4 JUN 2012
DOI: 10.1111/j.1447-0594.2012.00866.x
Issue
Geriatrics & Gerontology International

Geriatrics & Gerontology International

Volume 13, Issue 1, pages 90–97, January 2013
Article has an altmetric score of 3


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How to Cite

Sakurai, H., Hanyu, H., Sato, T., Kume, K., Hirao, K., Kanetaka, H. and Iwamoto, T. (2013), Effects of cilostazol on cognition and regional cerebral blood flow in patients with Alzheimer's disease and cerebrovascular disease: A pilot study. Geriatrics & Gerontology International, 13: 90–97. doi: 10.1111/j.1447-0594.2012.00866.x

Author Information

  1. Department of Geriatric Medicine, Tokyo Medical University, Tokyo, Japan
*Dr Hirofumi Sakurai MD PhD, Department of Geriatric Medicine, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo 160-0023, Japan. Email: sakurah@tokyo-med.ac.jp

Publication History

  1. Issue online: 3 JAN 2013
  2. Version of Record online: 4 JUN 2012
  3. Accepted for publication 12 March 2012.

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Keywords:

  • Alzheimer's disease;
  • cerebral blood flow;
  • cerebrovascular disease;
  • cilostazol;
  • cognition
Aim:  It remains unknown whether antiplatelet agents have a preventive effect on cognitive decline in patients with Alzheimer's disease (AD). We investigated the effects of cilostazol, an antiplatelet agent and cyclic adenosine monophosphate phosphodiesterase 3 inhibitor, on cognition and regional cerebral blood flow (rCBF) in elderly patients with AD and cerebrovascular disease (CVD).
Methods:  A total of 20 patients with AD and CVD were randomly assigned to a cilostazol group (n = 11, 100 mg daily) or control group (n = 9, aspirin 100 mg or clopidogrel 50 mg–75 mg daily) for 6 months.
Results:  The cilostazol group did not show any statistically significant changes in cognitive function test scores, whereas the control group showed statistically significant cognitive decline on the Alzheimer's Disease Assessment Scale-Cognitive Subscale (Japanese version), Revised Wechsler Memory Scale (logical memory-I) and Trail Making Test-A. Analysis of covariance of treatment effect revealed that the cilostazol group showed increased rCBF in the right anterior cingulate lobe compared with baseline, whereas the control group showed decreased rCBF in the left middle temporal gyrus compared with baseline.
Conclusion:  These findings suggest that cilostazol might have a preventive effect on cognitive decline in patients with AD and CVD. Geriatr Gerontol Int 2013; 13: 90–97.
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