Low circulating acute brain-derived neurotrophic factor levels are associated with poor long-term functional outcome after ischemic stroke

So, What the hell is the solution? What do we need to do to increase BDNF levels? WHO IS GOING TO ANSWER THAT SIMPLE QUESTION AND ACTUALLY HELP SURVIVORS?
http://www.mdlinx.com/neurology/medical-news-article/2016/07/13/brain-derived-neurotrophic-factor-pathogenesis-risk-factors-serum-stroke/6735204/?category=top-read&page_id=1 
 

  Stanne TM, et al. – The clinicians performed this work to examine whether circulating concentrations of brain–derived neurotrophic factor (BDNF) are altered in the acute phase of ischemic stroke and whether they are connected with short– or long–term functional outcome. This study suggests that in the acute phase of ischemic stroke, circulating concentrations of BDNF protein are brought down and low levels are connected with poor long–term functional outcome. They added that to confirm these affiliations and to determine the predictive value of BDNF in stroke outcomes further studies are essential.

Methods

• In the Sahlgrenska Academy Study on Ischemic Stroke, serum concentrations of BDNF were measured.  
• To pursue this research the primary results were adjusted Rankin Scale (mRS) good (mRS score of 0–2) versus poor (mRS score of 3–6) at 3 months and 2 years after stroke, and good (mRS score of 0–2) versus poor (mRS score of 3–5) at 7 years after stroke.  

Results

•  Researchers found that acute concentrations of BDNF were significantly lower in ischemic stroke cases (n=491) compared with controls (n=513).
• With 3-month outcome, BDNF concentrations were not significantly associated.
• The present study showed that patients with BDNF in the lowest tertile had an expanded risk of experiencing a poor outcome both at 2-year and 7-year follow-up, and these affiliations were independent of vascular risk factors and stroke severity (odds ratio, 2.6; confidence intervals, 1.4–4.9; P=0.002 and odds ratio, 2.1; confidence intervals, 1.1–3.9; P=0.028, respectively).  

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