Thursday, July 14, 2016

Modulating adult neurogenesis through dietary interventions

I bet even with this your doctor will not setup a diet stroke protocol. If s/he doesn't do that you really need to have a talk with the president of the hospital about the competency of the stroke department head and your doctor. It is up to us stroke survivors to clear out all the dead wood in the stroke world, they will not police and correct themselves. Proven by decades of little to no progress in stroke.
http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=10391689&fileId=S0954422416000081

Christine Heberden 

Micalis Institute, INRA, AgroParisTech, Université Paris-Saclay, 78350 Jouy-en-Josas, France
Abstract
Three areas in the brain continuously generate new neurons throughout life: the subventricular zone lining the lateral ventricles, the dentate gyrus in the hippocampus and the median eminence in the hypothalamus. These areas harbour neural stem cells, which contribute to neural repair by generating daughter cells that then become functional neurons or glia. Impaired neurogenesis leads to detrimental consequences, such as depression, decline of cognitive abilities and obesity. Adult neurogenesis is a versatile process that can be modulated either positively or negatively by many effectors, external or endogenous. Diet can modify neurogenesis both ways, either directly by ways of food-borne molecules, or possibly by the modifications induced on gut microbiota composition. It is therefore critical to define dietary strategies optimal for the maintenance of the stem cell pools.
Key words
  • Neurogenesis;
  • Neural stem cells;
  • Brain
Abbreviations
  • AMPK:AMP-activated protein kinase;
  • ARC:arcuate nucleus;
  • BDNF:brain-derived neurotrophic factor;
  • CA:cornu Ammonis;
  • CREB:cAMP response element binding protein;
  • DG:dentate gyrus;
  • ME:median eminence;
  • NSC:neural stem cells;
  • POMC:pro-opiomelanocortin;
  • Sirt1:sirtuin 1;
  • SVZ:subventricular zone
Correspondence
Corresponding author: Christine Heberden, email Christine.heberden@jouy.inra.fr

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