Oxamyl dipeptide caspase inhibitors developed for the treatment of stroke

Only 12 years old and I can find no further research on this or any translation to clinical use. This just continues to prove the incredible incompetence of our fucking failures of stroke associations.
http://www.sciencedirect.com/science/article/pii/S0960894X04003464

• Steven D. Linton^{a, ,} ,
• Teresa Aja^a,
• Peter R. Allegrini^b,
• Thomas L. Deckwerth^a,
• Jose-Luis Diaz^a,
• Bastian Hengerer^b,
• Julia Herrmann^a,
• Kathy G. Jahangiri^a,
• Joerg Kallen^b,
• Donald S. Karanewsky^a,
• Steven P. Meduna^a,
• Kip Nalley^a,
• Edward D. Robinson^a,
• Silvio Roggo^b,
• Giorgio Rovelli^b,
• Andre Sauter^b,
• Robert O. Sayers^a,
• Albert Schmitz^b,
• Robert Smidt^a,
• Robert J. Ternansky^a,
• Kevin J. Tomaselli^a,
• Brett R. Ullman^a,
• Christoph Wiessner^b,
• Joe C. Wu^a

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http://dx.doi.org/10.1016/j.bmcl.2003.12.106

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Abstract

Structural modifications were made to a previously described acyl dipeptide caspase inhibitor, leading to the oxamyl dipeptide series. Subsequent SAR studies directed toward the warhead, P2, and P4 regions of this novel peptidomimetic are described herein.

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Structural modifications were made to a previously described acyl dipeptide caspase inhibitor, leading to the oxamyl dipeptide series. Subsequent SAR studies directed toward the warhead, P2, and P4 regions of this novel peptidomimetic are described herein.

Corresponding author. Fax: +1-858-625-2677

Copyright © 2004 Elsevier Ltd. All rights reserved.

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