Temple scientists use hydrogen sulfide to restore stem cell-mediated blood flow in ischemic limbs of diabetic mice

Not that this directly helps stroke survivors but shit hydrogen sulfide research back to 2013 proved helpful for survivors. 7 posts on it here.  But shit once again nothing seems to have been done that might actually help stroke survivors. I blame our fucking failures of stroke associations, great at doing nothing for survivors.
http://www.mdlinx.com/internal-medicine/top-medical-news/article/2016/09/23/6

Temple Health

Hydrogen sulfide is a noxious gas, but in the human body it serves important functions as a gaseous signaling molecule. Among those functions is to protect the tone and cell function of blood vessels, which according to scientists at the Lewis Katz School of Medicine at Temple University (LKSOM) could prove critical in preventing limb amputation in patients with diabetes, a major complication of which is a painful reduction in limb blood flow known as critical limb ischemia (CLI). In a new study, the researchers are the first to show in diabetic animals that induced hydrogen sulfide production in bone marrow stem cells can effectively repair vessel tone and limb circulation. The study was published online September 22 in the journal Circulation. To determine whether hydrogen sulfide deficiency predisposed diabetic stem cells to abnormalities that undermine their function, Dr. Kishore and colleagues isolated bone marrow cells from nondiabetic and diabetic mice and examined the cells for differences in levels of hydrogen sulfide–synthesizing enzymes. They found that protein levels of an enzyme known as cystathionine gamma–lyase (CSE) were significantly decreased in diabetic bone marrow cells, accounting for the animals' hydrogen sulfide deficiency. The researchers then introduced the CSE gene into bone marrow cells isolated from diabetic mice to induce CSE overexpression and injected the cells back into the animals. The treatment resulted in dramatic improvements in blood vessel formation and blood flow. Remarkably, simple dietary supplementation with a hydrogen sulfide donor compound likewise restored hydrogen sulfide levels and improved limb circulation, enabling partial limb rescue. Blood flow was further increased when the special diet was combined with conventional stem cell therapy for CLI.