Association Between Sarcopenia(Muscle loss) and Cognitive Impairment: A Systematic Review and Meta-Analysis

What protocols is your doctor using to make sure you have no muscle loss? Hemiplegia is not an excuse for allowing this atrophy.  This goes back to cause and effect, if your doctor has valid interventions for these 5 causes of neuronal cascade of death, then you would have much fewer dead and damaged neurons allowing you to move around much better. Does your doctor even understand this concept? And no followup studies will be done so we will never know exactly the relationship and the urgency to solve this for stroke survivors.
 http://www.jamda.com/article/S1525-8610%2816%2930428-5/fulltext?rss=yes

Ke-Vin Chang, MD, PhD

,

Tsai-Hsuan Hsu, MS

,

Wei-Ting Wu, MD

,

Kuo-Chin Huang, MD, PhD

,

Der-Sheng Han, MD, PhDPress enter key for correspondence informationPress enter key to Email the author

DOI: http://dx.doi.org/10.1016/j.jamda.2016.09.013

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Abstract

Background

Sarcopenia, a gradual loss of muscle mass and function, has been associated with poor health outcomes. Its correlation with another age-related degenerative process, impaired cognition, remains uncertain. This meta-analysis aimed to determine whether there is an association between sarcopenia and cognitive impairment.

Methods

PubMed and Scopus were searched for observational studies that investigated the association between sarcopenia and cognitive dysfunction. Participants’ demographics and measurements, definition of sarcopenia, and tools for evaluating cognitive function were retrieved. The correlations between sarcopenia and cognitive impairment were expressed as crude and adjusted odds ratios with 95% confidence intervals (CIs).

Results

Seven cross-sectional studies comprising 5994 participants were included. The crude and adjusted odds ratios were 2.926 (95% CI, 2.297–3.728) and 2.246 (95% CI, 1.210–4.168), respectively. The subgroup analysis showed that different target populations and sex specificity did not significantly modify the association, whereas the tools for evaluating cognitive function and modalities for measuring body composition did.

Conclusions

Sarcopenia was independently associated with cognitive impairment. Future cohort studies are warranted to clarify the causal correlation. The inclusion of relevant biomarkers and functional measurements is also recommended to elucidate the underlying biological mechanism.

Keywords:

Sarcopenia, cognition, dementia, muscle, aging

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The study was funded by the research funding of the Community and Geriatric Research Center, National Taiwan University Hospital, Bei-Hu Branch.
The authors declare no conflicts of interest.

© 2016 AMDA - The Society for Post-Acute and Long-Term Care Medicine.