Cannabidiol reduces neuroinflammation and promotes neuroplasticity and functional recovery after brain ischemia

Where the fuck is the stroke protocol writeup so survivors can benefit from this knowledge. Getting the knowledge disseminated through doctors has been proven to be a complete failure. Let's do this through survivors. It will be much faster and complete. Write up the damn protocol.  If you can't do that until human research is done, get cracking on that human research. Survivors are adversely impacted by delays. Get going.
http://www.sciencedirect.com/science/article/pii/S0278584616302524

• Marco Aurélio Mori^a,
• Erika Meyer^a,
• Ligia Mendes Soares^a,
• Humberto Milani^a,
• Francisco Silveira Guimarães^b,
• Rúbia Maria Weffort de Oliveira^{a, ,}

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http://dx.doi.org/10.1016/j.pnpbp.2016.11.005

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Abstract

This study investigated the effects of cannabidiol (CBD), a non-psychotomimetic phytochemical present in Cannabis sativa, on the cognitive and emotional impairments induced by bilateral common carotid artery occlusion (BCCAO) in mice. Using a multi-tiered behavioral testing battery during 21 days, we found that BCCAO mice exhibited long-lasting functional deficits reflected by increase in anxiety-like behavior (day 9), memory impairments (days 12–18) and despair-like behavior (day 21). Short-term CBD 10 mg/kg treatment prevented the cognitive and emotional impairments, attenuated hippocampal neurodegeneration and white matter (WM) injury, and reduced glial response that were induced by BCCAO. In addition, ischemic mice treated with CBD exhibited an increase in the hippocampal brain derived neurotrophic factor (BDNF) protein levels. CBD also stimulated neurogenesis and promoted dendritic restructuring in the hippocampus of BCCAO animals. Collectively, the present results demonstrate that short-term CBD treatment results in global functional recovery in ischemic mice and impacts multiple and distinct targets involved in the pathophysiology of brain ischemic injury.