Propofol inhibits neurogenesis of rat neural stem cells by upregulating microRNA-141-3p

So don't get this drug that killed Michael Jackson.
http://online.liebertpub.com/doi/abs/10.1089/scd.2016.0257
To cite this article:
Dr. Qiliang Jiang, Yingwei Wang, and Xueyin Shi. Stem Cells and Development. October 2016, ahead of print. doi:10.1089/scd.2016.0257.

Online Ahead of Editing: October 31, 2016

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Author information

Dr. Qiliang JiangYingwei WangXueyin Shi

Accepted: 08 23 2016
Received: 08 23 2016

ABSTRACT

Prolonged or high-dose exposure to anaesthetics, such as propofol, can cause brain cell degeneration and subsequent long-term learning or memory deficits, particularly in the developing brain. However, the cellular and molecular mechanisms underlying the deleterious effects of propofol at certain stages of development remain unclear. Here we found that propofol inhibited the proliferation, neuronal differentiation, and migration of NSCs while upregulating miR-141-3p. Silencing of miR-141-3p abrogated the effects of propofol on NSC neurogenesis. Propofol treatment downregulated IGF2BP2, a direct target of miR-141-3p, whereas overexpression of IGF2BP2 attenuated the effects of propofol and miR-141-3p on NSC neurogenesis. In short, propofol inhibits NSC neurogenesis via a mechanism involving the miR-141-3p/IGF2BP2 axis. Our results may provide a potential approach for preventing the neurodegenerative effects of propofol in the developing brain.