Brain-derived neurotrophic factor protects against neurodegeneration in a mouse model of human tauopathy

What is your doctor doing to make sure your BDNF is high enough to prevent neurodegeneration? Or is s/he waiting for decades for human research to be done? Thus dooming you to dementia/Alzheimers. If you won't go down without a fight you will need to start screaming at your doctors for help in solving this problem. Now, not 50 years from now.
https://espace.library.uq.edu.au/view/UQ:413018
Jiao, S.-S., Shen, L.-L., Zhu, C., Bu, X.-L., Liu, Y.-H., Liu, C.-H., Yao, X.-Q., Zhang, L.-L., Zhou, H.-D., Walker, D. G., Tan, J., Götz, J., Zhou, X.-F. and Wang, Y.-J. (2016) Brain-derived neurotrophic factor protects against neurodegeneration in a mouse model of human tauopathy. Translational Psychiatry, 6 10: . doi:10.1038/tp.2016.186
Abstract Collection year 2017 Language

Author	Jiao, S.-S. Shen, L.-L. Zhu, C. Bu, X.-L. Liu, Y.-H. Liu, C.-H. Yao, X.-Q. Zhang, L.-L. Zhou, H.-D. Walker, D. G. Tan, J. Götz, J. Zhou, X.-F. Wang, Y.-J.
Title	Brain-derived neurotrophic factor protects against neurodegeneration in a mouse model of human tauopathy
Journal name	Translational Psychiatry   Check publisher's open access policy
ISSN	2158-3188
Publication date	2016-10-04
Sub-type	Article (original research)
DOI	10.1038/tp.2016.186
Open Access Status	DOI
Volume	6
Issue	10
Total pages	11
Place of publication	London, United Kingdom
Publisher	Nature Publishing Group
eng
Reduced expression of brain-derived neurotrophic factor (BDNF) has a crucial role in the pathogenesis of Alzheimer’s disease (AD), which is characterized with the formation of neuritic plaques consisting of amyloid-beta (Aβ) and neurofibrillary tangles composed of hyperphosphorylated tau protein. A growing body of evidence indicates a potential protective effect of BDNF against Aβ-induced neurotoxicity in AD mouse models. However, the direct therapeutic effect of BDNF supplement on tauopathy in AD remains to be established. Here, we found that the BDNF level was reduced in the serum and brain of AD patients and P301L transgenic mice (a mouse model of tauopathy). Intralateral ventricle injection of adeno-associated virus carrying the gene encoding human BDNF (AAV-BDNF) achieved stable expression of BDNF gene and restored the BDNF level in the brains of P301L mice. Restoration of the BDNF level attenuated behavioral deficits, prevented neuron loss, alleviated synaptic degeneration and reduced neuronal abnormality, but did not affect tau hyperphosphorylation level in the brains of P301L mice. Long-term expression of AAV-BDNF in the brain was well tolerated by the mice. These findings suggest that the gene delivery of BDNF is a promising treatment for tau-related neurodegeneration for AD and other neurodegenerative disorders with tauopathy.