https://www.mdlinx.com/internal-medicine/medical-news-article/2017/01/19/tomato-lycopene-intervention-cardiovascular-risk-factors/7012407/?
Atherosclerosis, 01/19/2017
Cheng
HM, et al. – This study suggests a positive influence of tomato
products and lycopene supplementation on blood lipids, blood pressure
and endothelial function. These outcomes support the development of
promising individualised nutritional strategies involving tomatoes to
tackle cardiovascular diseases (CVD).
Methods
- Researchers searched 3 databases including Medline, Web of science, and Scopus from inception to August 2016.
- Inclusion criteria were: intervention randomised controlled trials reporting effects of tomato products and lycopene supplementation on CV risk factors among adult subjects >18 years of age.
- The outcomes of interest included blood lipids (total-, HDL-, LDL-cholesterol, triglycerides, oxidised-LDL), endothelial function (flow-mediated dilation (FMD), pulse wave velocity (PWV)) and blood pressure (BP) inflammatory factors (CRP, IL-6) and adhesion molecules (ICAM-1).
- They used random-effects models to determine the pooled effect sizes.
Results
- Data showed that out of 1189 publications identified, 21 fulfilled inclusion criteria and were meta-analysed.
- Overall, findings demonstrated that interventions supplementing tomato were associated with significant reductions in LDL-cholesterol (-0.22 mmol/L; p = 0.006), IL-6 (standardised mean difference -0.25; p = 0.03), and improvements in FMD (2.53%; p = 0.01); while lycopene supplementation reduced Systolic-BP (-5.66 mmHg; p = 0.002).
- Additionally, it was noted that no other outcome was significantly affected by these interventions.
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