https://www.mdlinx.com/internal-medicine/medical-news-article/2017/02/14/lqts-long-qt-syndrome-qtc-corrected/7051598/?
International Journal of Cardiology, 02/14/2017
Gray
B, et al. – This study suggests that caffeinated energy drinks markedly
alter the cardiovascular dynamics in patients with long QT syndrome
(LQTS). These drinks specifically trigger an acute increase in blood
pressure. Moreover, these should be cautiously consumed by young
patients considering their ability to trigger dangerous QTc prolongation
in some LQTS patients.
Methods
- From 2014–2016, 24 LQTS patients aged 16–50 years were recruited to a randomized, double-blind, cross-over study of energy drink (ED) versus control (CD) with participants acting as their own controls (one week washout).
- The primary study outcome was an increase in corrected QT interval (QTc) by >20ms and, secondary outcomes were changes in systolic and diastolic blood pressure.
Results
- Findings demonstrated that in 24 patients with LQTS (no dropout), mean age was 29 ± 9 years, 13/24 (54%) were female, and 8/24 (33%) were probands. Intention to treat analysis revealed no significant change in QTc with ED compared with CD (12 ± 28 ms vs 16 ± 27 ms, 3% vs 4%, p = 0.71).
- Researchers observed that the systolic and diastolic blood pressure significantly increased with ED compared to CD (peak change 7 ± 16 mmHg vs 1 ± 16 mmHg, 6% vs 0.8%, p = 0.046 and 8 ± 10 vs 2 ± 9 mmHg, 11% vs 3% p = 0.01 respectively).
- They found that these changes correlated with significant increases in serum caffeine (14.6 ± 11.3 vs 0.5 ± 0.1μmol/L, p < 0.001) and serum taurine (737 ± 199 vs -59 ± 22μmol/L, p < 0.001).
- Also, data reported three patients with dangerous QTc prolongation of ≥50ms following energy drink consumption.
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