Relationship between coffee consumption and stroke risk in Korean population: the Health Examinees (HEXA) Study

How many research articles on the benefits of coffee will your doctor have to ignore before doing ANYTHING about creating a drink protocol? I bet that will never occur. You probably have to risk drinking coffee without your doctors prescription.  But only for women in this study.
http://nutritionj.biomedcentral.com/articles/10.1186/s12937-017-0232-y

• Jeeyoo Lee,
• Ji-Eun Lee and
• Yuri KimEmail author

Nutrition Journal201716:7

DOI: 10.1186/s12937-017-0232-y

©  The Author(s). 2017

Received: 27 October 2016

Accepted: 23 January 2017

Published: 31 January 2017

Open Peer Review reports

Abstract

Background

Although coffee consumption is increasing rapidly, the results of previous studies regarding the association between coffee consumption and stroke risk have been conflicting. This was a multi-center cross-sectional study that aimed to evaluate the relationship between coffee consumption and stroke risk in Korean population.

Methods

Data were obtained from the Health Examinees (HEXA) Study, which involved 146,830 individuals aged 40–69 years. Coffee consumption was categorized as none, < 1 cup/day, 1 to < 3 cups/day, and ≥ 3 cups/day. We used logistic regression models to examine the association between coffee consumption and the risk of stroke while controlling for potential confounders and performed subgroup analyses.

Results

After adjusting for age and various possible confounders, high coffee consumption was associated with a 38% lower odds ratio for stroke in women (none vs. ≥ 3 cups/day: OR, 0.62; 95% CI 0.47-0.81; P for trend < 0.0001). No significant association was found in men (none vs. ≥ 3 cups/day: OR, 0.84; 95% CI, 0.66-1.07; P for trend = 0.1515). In analyses stratified by covariates, an inverse association between coffee consumption and stroke risk was most evident among healthy women who were younger, non-obese, non-hypertensive, non-diabetic, non-smokers, and non-alcohol drinkers.

Conclusion

Our results suggest that higher coffee consumption may have protective benefits with regards to stroke risk in middle-aged Korean women.