Tuesday, March 14, 2017

Silent brain infarction and risk of future stroke

My doctor told me I had multiple small infarcts in my white matter. Of course he never showed me anything to prove that assertion or did one damn thing to correct the problems from that. It was basically, you're screwed, deal with this on your own, I know and will do nothing. 
https://www.mdlinx.com/internal-medicine/medical-news-article/2016/03/11/brain-infarction-infarction-magnetic-resonance-imaging/6553395/?
This article is featured in Smartest Doc. See if you can answer related questions.
Start Review!
Stroke, 03/11/2016
The authors performed a systematic review and meta–analysis to summarize the association between magnetic resonance imaging–defined silent brain infarction (SBI) and future stroke risk. SBI is present in ≈1 in 5 stroke–free older adults and is associated with a 2–fold increased risk of future stroke. Future studies of in–depth stroke risk evaluations and intensive prevention measures are warranted in patients with clinically unrecognized radiologically evident brain infarctions.

Methods

  • The authors searched the medical literature to identify cohort studies involving adults with SBI detected by magnetic resonance imaging who were subsequently followed up for incident clinically defined stroke.
  • Study data and quality assessment were recorded in duplicate with disagreements in data extraction resolved by a third reader.
  • Strength association between magnetic resonance imaging-detected SBI and future symptomatic stroke was measured by an hazard ratio.

Results

  • The meta-analysis included 13 studies (14 764 subjects) with a mean follow-up ranging from 25.7 to 174 months.
  • SBI predicted the occurrence of stroke with a random effects crude relative risk of 2.94 (95% confidence interval, 2.24-3.86, P<0.001; Q=39.65, P<0.001).
  • In the 8 studies of 10 427 subjects providing hazard ratio adjusted for cardiovascular risk factors, SBI was an independent predictor of incident stroke (hazard ratio, 2.08 [95% confidence interval, 1.69-2.56; P<0.001]; Q=8.99; P=0.25).
  • In a subgroup analysis pooling 9483 stroke-free individuals from large population-based studies, SBI was present in ≈18% of participants and remained a strong predictor of future stroke (hazard ratio, 2.06 [95% confidence interval, 1.64-2.59]; P<0.01).
Go to PubMed Go to Abstract Print Article Summary Cat 2 CME Report

No comments:

Post a Comment