Vitamin D supplementation improves simvastatin-mediated decline in exercise performance: A randomized, double-blind, placebo-controlled study

Would the same vitamin D supplementation be necessary for stroke survivors taking statins? Ask your doctor. Would this help our fatigue? A fuckingly simple question that will never be answered because we have NO stroke strategy or leadership.
https://www.mdlinx.com/internal-medicine/medical-news-article/2017/03/02/cardiorespiratory-fitness/7072803/?

Journal of Diabetes, 03/02/2017 Singla M, et al.

In the present study, researchers find out the impact of vitamin D supplementation on simvastatin–mediated changes in cardiorespiratory fitness and skeletal muscle mitochondrial content after exercise in adults with type 2 diabetes mellitus (T2DM). The outcome suggests simvastatin tends to cause deterioration in exercise–mediated cardiorespiratory fitness and skeletal muscle mitochondrial content in adults with type 2 diabetes, which is blunted by vitamin D supplementation.

Methods

• For this study they enrolled 25–50 years old vitamin D deficient T2DM patients.
• Participants performed moderate intensity aerobic exercise for 3–months and were randomized to receive simvastatin 40 mg per day, simvastatin 40 mg daily and vitamin D 60,000 units once weekly, or vitamin D 60,000 units once weekly.
• The primary results were cardiorespiratory fitness (peak oxygen consumption) and skeletal muscle mitochondrial content (citrate synthase activity in vastus lateralis muscle).

Results

• A sum of 28 patients finished the study.
• Cardiorespiratory fitness reduced by 8.4% (p < 0.05) following 3 months of simvastatin therapy.
• Vitamin D supplementation blunted the decline in cardiorespiratory fitness to 0.6% (p < 0.05 for between–group difference in change from baseline).
• Similarly, skeletal muscle mitochondrial content reduced by 3.6% with simvastatin however enhanced by 12.1% on supplementation with vitamin D, although the between– group difference was insignificant.
• Vitamin D alone expanded cardiorespiratory fitness and mitochondrial content by 7.1% (p < 0.05) and 16.7% respectively.

Go to PubMed Go to Abstract Print Article Summary Cat 2 CME Report