Tuesday, May 2, 2017

Improving neurorepair in stroke brain through endogenous neurogenesis-enhancing drugs


Who gives a fuck about discussing and reviewing possible drugs you lazy fucking idiots. We need protocols and translational efforts that actually get survivors to 100% recovery. Don't just sit on your fucking ass and discuss, trillions of neurons are dying every second.
I guess you are on your own to get the research and hire researchers to solve the problem. No one else is going to do it.  I guess everyone in stroke takes their cues from our fucking failures of stroke associations doing 'All talk and no action' or 'All hat and no cattle'.

https://www.ncbi.nlm.nih.gov/pubmed/28447573

Abstract

Stroke induces not only cell death but also neurorepair. De novo neurogenesis has been found in the subventricular zone(SVZ) of adult mammalian brain days after stroke. Most of these newly generated cells die shortly after the insult. Recent studies have shown that pharmacological manipulation can improve the survival of endogenous neuroprogenitor cells and neural regeneration in stroke rats. As these drugs target the endogenous reparative processes which occur days after stroke, they may provide a prolonged window for stroke therapy. Here, we discuss endogenous neurogenesis-enhancing drugs, and review the general status of stroke therapeutics in evaluating the field of pharmacotherapy for stroke.
PMID:
28447573
DOI:
10.3727/096368917X695650


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