Restoring auditory cortex plasticity in adult mice by restricting thalamic adenosine signaling

I would expect human testing to begin almost immediately. We need neuroplasticity up the wazoo since no one yet knows how to make neuroplasticity repeatable on demand. Of course that will never occur since we have NO stroke leadership and NO stroke strategy.
 http://science.sciencemag.org/content/356/6345/1352

1. Jay A. Blundon¹,*,
2. Noah C. Roy¹,*,
3. Brett J. W. Teubner¹,
4. Jing Yu¹,
5. Tae-Yeon Eom¹,
6. K. Jake Sample¹,
7. Amar Pani¹,†,
8. Richard J. Smeyne¹,‡,
9. Seung Baek Han¹,
10. Ryan A. Kerekes²,
11. Derek C. Rose²,
12. Troy A. Hackett³,
13. Pradeep K. Vuppala⁴,§,
14. Burgess B. Freeman III⁴,
15. Stanislav S. Zakharenko¹,||

+ See all authors and affiliations

Science  30 Jun 2017:
Vol. 356, Issue 6345, pp. 1352-1356
DOI: 10.1126/science.aaf4612

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Abstract

Circuits in the auditory cortex are highly susceptible to acoustic influences during an early postnatal critical period. The auditory cortex selectively expands neural representations of enriched acoustic stimuli, a process important for human language acquisition. Adults lack this plasticity. Here we show in the murine auditory cortex that juvenile plasticity can be reestablished in adulthood if acoustic stimuli are paired with disruption of ecto-5′-nucleotidase–dependent adenosine production or A₁–adenosine receptor signaling in the auditory thalamus. This plasticity occurs at the level of cortical maps and individual neurons in the auditory cortex of awake adult mice and is associated with long-term improvement of tone-discrimination abilities. We conclude that, in adult mice, disrupting adenosine signaling in the thalamus rejuvenates plasticity in the auditory cortex and improves auditory perception.