Objectives
Stroke
is a leading cause of disability. Alternative and more effective
techniques for stroke rehabilitation have been sought to overcome
limitations of conventional therapies. Repetitive transcranial magnetic
stimulation (rTMS) arises as a promising tool in this context. This
systematic review aims to provide a state of the art on the application
of rTMS in stroke patients and to assess its effectiveness in clinical
rehabilitation of motor function.
Methods
Studies
included in this review were identified by searching PubMed and ISI Web
of Science. The search terms were (rTMS OR “repetitive transcranial
magnetic stimulation”) AND (stroke OR “cerebrovascular accident” OR CVA)
AND (rehab OR rehabilitation OR recover*). The retrieved records were
assessed for eligibility and the most relevant features extracted to a
summary table.
Results
Seventy
out of 691 records were deemed eligible, according to the selection
criteria. The majority of the articles report rTMS showing potential in
improving motor function, although some negative reports, all from
randomized controlled trials, contradict this claim. Future studies are
needed because there is a possibility that a bias for non-publication of
negative results may be present.
Conclusions
rTMS
has been shown to be a promising tool for stroke rehabilitation, in
spite of the lack of standard operational procedures and harmonization.
Efforts should be devoted to provide a greater understanding of the
underlying mechanisms and protocol standardization.
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