Effect of glial cells on remyelination after spinal cord injury

Do we need this after a stroke? Have we demyelinated neurons in the brain? What does your doctor know about this and what is the protocol to fix it?  Scream at your doctor if you have to get her attention about actually fixing you up to 100% recovery. 

Effect of glial cells on remyelination after spinal cord injury

Hai-feng Wang¹, Xing-kai Liu², Rui Li³, Ping Zhang², Ze Chu⁴, Chun-li Wang², Hua-rui Liu², Jun Qi², Guo-yue Lv², Guang-yi Wang², Bin Liu M.D. ⁵, Yan Li⁶, Yuan-yi Wang M.D. ^7
1 Department of Neurosurgery, First Hospital of Jilin University, Changchun, Jilin Province, China
² Department of Hepatobiliary and Pancreas Surgery, First Hospital of Jilin University, Changchun, Jilin Province, China
³ Hand & Foot Surgery and Reparative & Reconstruction Surgery Center, Second Hospital of Jilin University, Changchun, Jilin Province, China
⁴ Department of Emergency, First Hospital of Jilin University, Changchun, Jilin Province, China
⁵ Department of Cardiology, First Hospital of Jilin University, Changchun, Jilin Province, China
⁶ Department of Surgery, School of Medicine, University of Louisville, Louisville, KY, USA
⁷ Department of Orthopedics, First Hospital of Jilin University, Changchun, Jilin Province, China

Date of Acceptance	14-Sep-2017
Date of Web Publication	10-Nov-2017

Correspondence Address:
Bin Liu
Department of Cardiology, First Hospital of Jilin University, Changchun, Jilin Province
China
Yuan-yi Wang
Department of Orthopedics, First Hospital of Jilin University, Changchun, Jilin Province
China

Source of Support: This work was supported by the National Natural Science Foundation of China, No. 81601957., Conflict of Interest: None

DOI: 10.4103/1673-5374.217354

Abstract

Remyelination plays a key role in functional recovery of axons after spinal cord injury. Glial cells are the most abundant cells in the central nervous system. When spinal cord injury occurs, many glial cells at the lesion site are immediately activated, and different cells differentially affect inflammatory reactions after injury. In this review, we aim to discuss the core role of oligodendrocyte precursor cells and crosstalk with the rest of glia and their subcategories in the remyelination process. Activated astrocytes influence proliferation, differentiation, and maturation of oligodendrocyte precursor cells, while activated microglia alter remyelination by regulating the inflammatory reaction after spinal cord injury. Understanding the interaction between oligodendrocyte precursor cells and the rest of glia is necessary when designing a therapeutic plan of remyelination after spinal cord injury.