So to get better BDNF your doctor has to get you a diet protocol. Do you really think that will occur? 28 pages for your doctor to figure out.
Enrico Sangiovanni, Paola Brivio, Mario Dell’Agli, Francesca Calabrese
Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Milan, Italy
* Correspondence: Francesca Calabrese; Dept. Pharmacological and Biomolecular Sciences, University of Milan, Via Balzaretti 9, 20133 Milan, Italy; francesca.calabrese@unimi.it
Abstract: The involvement of Brain-derived neurotrophic factor (BDNF) in different central
nervous system (CNS) diseases suggests that this neurotrophin may represent an interesting and
reliable therapeutic target. Accordingly, the search for new compounds, also from natural sources,
able to modulate BDNF has been increasingly explored. The present review critically considers the
available literature on the effects of botanicals acting on CNS, focusing on BDNF. Botanicals
considered were: Bacopa monnieri (L.) Pennell, Coffea arabica L., Crocus sativus L., Eleutherococcus senticosus Maxim., Camellia sinensis (L.) Kuntze (green tea), Ginkgo biloba L., Hypericum perforatum L., Olea europea L. (olive oil), Panax ginseng C.A. Meyer, Rhodiola rosea L., Salvia miltiorrhiza Bunge, Vitis vinifera L., Withania somnifera (L.) Dunal, and Perilla frutescens (L.) Britton. The effect of the active principles responsible for the efficacy of the extracts is reviewed and discussed as well. The high number of articles published (more than one hundred manuscripts for 14 botanicals) supports the growing interest in the use of natural products as BDNF modulators. The studies reported herein strengthen the hypothesis that botanicals may be considered useful modulators of BDNF in CNS diseases (i.e. cognitive deficits), without high side effects. Further clinical studies
are mandatory to confirm botanicals as preventive agents or as useful adjuvant to the pharmacological treatment.
Keywords: cognition; depression
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