Effectiveness of botulinum toxin for lower limbs spasticity after stroke: A systematic review and meta-analysis

O fuck, another piece of lazy research suggesting further followup instead of coming up with stroke protocols, just kicking the can down the road and taking no responsibility for anything in stroke.
http://search.naric.com/research/rehab/redesign_record.cfm?search=2&type=all&criteria=J77358&phrase=no&rec=135295&article_source=Rehab&international=0&international_language=&international_location=
Topics in Stroke Rehabilitation , Volume 23(3) , Pgs. 217-223.

NARIC Accession Number: J77358.  What's this?
ISSN: 1074-9357.
Author(s): Wu, Tao; Li, Jian; Song, Hai X.; Dong, Yan.
Publication Year: 2016.
Number of Pages: 7.
Abstract: Study evaluated the current evidence on the effectiveness of botulinum toxin (BTX) injection for lower-limb spasticity after stroke. Electronic databases were searched from their inception through week 23 of 2015 for randomized controlled trials (RCTs) comparing the clinical efficacy of BTX injection to placebo or conventional therapy on lower-limb spasticity after stroke. One thousand three hundred forty-three records were identified and among them, 7 RCTs (603 patients) were eligible for the final analysis. The authors constructed random effects models and calculated the mean difference (MD) or standardized mean difference for continuous outcomes. Analysis revealed a statistically significant decrease in muscle tone was observed at week 4 and week 12 after injection. Patients who received in BTX therapy were likely to have statistically significant increased Fugl-Meyer score compared to the control group at 24-weeks follow-up, with MD = 3.19. There was no difference in gait speed between two groups during whole follow-up period. In this meta-analysis, BTX showed more persistent clinical benefits in lower-limb spasticity and the Fugl-Meyer score than placebo in patients after stroke. These results suggest that BTX could be a useful and safe strategy for the treatment of lower-limb spasticity after stroke. Further investigation is required to determine the effectiveness of BTX injection for stroke patients with optimal timing and dose of intervention.
Descriptor Terms: DRUGS, LIMBS, LITERATURE REVIEWS, MUSCULAR IMPAIRMENTS, PHARMACOLOGY, SPASTICITY, STROKE.


Can this document be ordered through NARIC's document delivery service*?: Y.

Citation: Wu, Tao, Li, Jian, Song, Hai X., Dong, Yan. (2016). Effectiveness of botulinum toxin for lower limbs spasticity after stroke: A systematic review and meta-analysis.  Topics in Stroke Rehabilitation , 23(3), Pgs. 217-223. Retrieved 1/14/2018, from REHABDATA database.