Association of coffee consumption and non-motor symptoms in drug-naïve, early-stage Parkinson's disease

With your chance of getting Parkinsons post stroke and this news my choice of massive coffee consumption seems warranted. But don't listen to me, I'm not medically trained. Of course no amounts are given, so you'll have to guess.

Parkinson’s Disease May Have Link to Stroke

How coffee protects against Parkinson’s Aug. 2014

 

http://www.prd-journal.com/article/S1353-8020(18)30052-X/fulltext?rss=yes

Bang-Hoon Cho

,

Seong-Min ChoiCorrespondence information about the author Seong-Min ChoiEmail the author Seong-Min Choi

,

Joon-Tae Kim

,

Byeong C. Kim

PlumX Metrics

DOI: https://doi.org/10.1016/j.parkreldis.2018.02.016

Article Info

• Abstract

• Full Text

• References
• Supplemental Materials

Highlights

• •There is an inverse association between coffee consumption and non-motor symptoms (NMSs) of drug-naïve PD patients.
• •Coffee drinkers had a lower severity in several sub-items of the mood/cognition domain compared to non-coffee drinkers.
• •It is important to consider the history of coffee consumption in the assessment of NMSs of PD patients.

Abstract

Objective

Coffee consumption has an inverse association with the risk of Parkinson's disease (PD). The aim of this study was to investigate the association between coffee consumption and non-motor symptoms (NMSs) in patients with PD.

Methods

In this cross-sectional study, we included 196 early-stage, treatment-naïve PD patients. Coffee consumption history was obtained via semi-structured interviews. NMSs were assessed using the Non-Motor Symptom assessment scale (NMSS).

Results

Of the 196 patients with PD, 136 (69.3%) were categorized as coffee drinkers and 60 (30.6%) were non-drinkers. Coffee drinkers were younger, predominantly male, were younger in age at symptom onset, had lower Unified Parkinson's Disease Rating Scale motor and Beck Depression Inventory scores, and higher Mini-Mental State Examination scores than non-coffee drinkers. After adjustment, coffee drinking was significantly inversely associated with the prevalence of lack of motivation, anhedonia, and lack of pleasure, which were less frequent in coffee drinkers. Total NMSS scores were lower in coffee drinkers than in non-drinkers (p = 0.047). In particular, coffee drinking was significantly associated with a reduced severity of the mood/cognition domain of NMSS (p = 0.003). After correcting for multiple testing, there were no significant differences in the prevalence of NMSs, but there were significant differences in the severity of NMSs between coffee drinkers and non-drinkers.

Conclusion

There is a negative association between coffee consumption and the severity of the mood/cognition domain of NMSS in patients with PD. Clinicians should consider the history of coffee consumption in the assessment of NMSs in PD.