Saturday, May 19, 2018

Effect of Combination Therapy with Neuroprotective and Vasoprotective Agents on Cerebral Ischemia

Since this significantly reduced infarct volume in rabbits your doctor and stroke hospital can once again be incompetent in not following this up with researcher collaboration. You're screwed because NOTHING will be done with this. No real hurry to do this, 5-8 hours after onset.
https://www.cambridge.org/core/journals/canadian-journal-of-neurological-sciences/article/effect-of-combination-therapy-with-neuroprotective-and-vasoprotective-agents-on-cerebral-ischemia/A0C31F17ACF68D3D3DA9AFF33853ACAE

Abstract
Because most tested drugs are active against only one of the damaging processes associated with stroke, other mechanisms may cause cellular death. Thus, a combination of protective agents targeting different pathophysiological mechanisms may obtain better effects than a single agent. The major objective of this study was to investigate the effect of combination therapy with vascular endothelial growth factor (VEGF) and nerve growth factor (NGF) after controlled ischemic brain injury in rabbits. Methods: Animals were randomly assigned to one of the following groups: sham group, saline-treated control group or NGF+VEGF-treated group. Animals received an intracerebral microinjection of VEGF and NGF or saline at 5 or 8 hours after ischemia. The two specified time points of administration were greater than or equal to the existing therapeutic time window for monoterapy with VEGF or NGF alone (3 or 5 hours of ischemia). Infarct volume, water content, neurological deficits, neural cell apoptosis and the expression of caspase-3 and Bcl-2 were measured. Results: Compared with saline-treated controls, the combination therapy of VEGF and NGF significantly reduced infarct volume, water content, neural cell apoptosis and the expression of caspase-3, up-regulated the expression of Bcl-2 and improved functional recovery (both p<0.01) when administered 5 or 8 hours after ischemia. The earlier the administration the better the neuroprotection. Conclusions: These results showed that the combination therapy with VEGF and NGF provided neuroprotective effects. In addition, the time window of combination treatment should be at least 8 hours after ischemia, which was wider than monotherapy.
Copyright
COPYRIGHT: © The Canadian Journal of Neurological Sciences Inc. 2018 
Corresponding author
Correspondence to: Jiping Yang, Department of Medical Imaging, The Second Hospital of Hebei Medical University, 215 West Heping Road, Shijiazhuang, 050000, Hebei Province, China. Email: ran0511@sina.com
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