Sunday, August 26, 2018

To Treat or Not to Treat? Exploring Factors Influencing r-tPA (Recombinant Tissue-Type Plasminogen Activator) Treatment Decisions for Minor Stroke

Every single stroke coming into your stroke hospital should have a protocol to follow. There is never a stroke that is too good to treat. You never magically recover from a stroke. Your doctor should never have to make a subjective decision. You have an objective damage diagnosis(The NIH Stroke Scale is not objective so we have a problem right from the start.). What should follow directly from that is a stroke protocol to remove the clot or stop the bleeding and then a protocol to stop the neuronal cascade of death or the hemorrhage cascade of death.  This is so fucking simple, why can't it be done?  Laziness? Incompetence? Or just don't care? No leadership? No strategy? Not my job?

To Treat or Not to Treat? Exploring Factors Influencing r-tPA (Recombinant Tissue-Type Plasminogen Activator) Treatment Decisions for Minor Stroke

The authors undertook this multicenter United States-based survey to explore factors that influence intravenous thrombolysis decisions patients with minor stroke, who constitute a controversial category of acute ischemic stroke. One hundred ninety-four physicians were across the United States with 150 vignettes using a variation of the following 7 factors that were agreed on by an expert panel as most likely to influence tPA (tissue-type plasminogen activator) administration: National Institutes of Health Stroke Scale (NIHSS) score(The NIH Stroke Scale is not objective so we have a problem right from the start.), NIHSS area of deficit with emphasis on 3 levels (visual/language/weakness), baseline functional status, previous ischemic stroke, previous intracerebral hemorrhage, recent use of anticoagulation, and temporal pattern of symptoms in first hour of emergency department care. One hundred fifty-six physicians returned complete vignettes and were included in the final analysis, 80% neurologists and 20% emergency department physicians; nearly 2/3 practiced in academic institutions and comprehensive stroke centers. On the 2 extremes of the spectrum, physicians were most likely to treat patients with higher NIHSS, stable course, and no prior hemorrhage or ischemic stroke and least likely to consider treatment in those with low NIHSS, preexisting disability, and recent stroke or hemorrhage. Overall, 4 of the 7 factors weighed heavily in physician decisions, in descending order: previous intracerebral hemorrhage, anticoagulation use, NIHSS score, and previous recent ischemic stroke. However, in a conjoint model, only 25% of the variability in decision-making was accounted for. The authors also explored the effect of individual physician characteristics, such as age, years of practice, sex, and area of training; they found no significant impact on the probability to use thrombolysis. Overall, a substantial proportion of the variability in decision-making in minor stroke remains currently unexplained. See p 1933.

No comments:

Post a Comment