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A Meta-Analysis of Tea Drinking and Risk of Parkinson's Disease
This article has been cited by other articles in PMC.
Abstract
Background. Many studies have reported an association between
tea drinking and Parkinson's disease (PD). Our purpose is to summarize
the available information and evaluate the risk of PD associated with
tea drinking.
Methods. We searched all publications in English
language on the association of tea drinking and PD risk published up to
December 2010. The pooled analysis was performed with Review Manager
5.0. Results. In total, eight articles including 1418 cases and
4250 controls were included in the meta-analysis. The pooled odds ratio
(95% CI) was 0.85 (0.74–0.98), which suggests the protective effect of
tea drinking in PD risks. Moreover, the summary OR (OR: 0.83, 95% CI =
0.69–0.99) for drinkers of ≤1 cup of tea per day versus nonconsumers and
that (OR: 0.96, 95% CI = 0.73–1.27) for drinkers of >1 cups of tea
per day versus nonconsumers showed that there was not an apparent
dose-response relationship. No indication for publication bias was
found.
Conclusions. This meta-analysis showed that tea drinking
can lower the risk of PD, while no apparent dose-response relationship
was found. Further effort is needed to fully understand the mechanism
underlying the beneficial effect of tea consumption in lowering PD risk.
1. Introduction
Parkinson's
disease (PD) is a common neurodegenerative disorder, and, with the
accelerated aging of human society, the prevalence of PD is expected to
rise steadily in future [1, 2].
Despite the pathogenesis of PD is not fully elucidated, many
epidemiological factors, such as coffee drinking and smoking, have been
demonstrated to lower the risk of PD [3–5].
Tea is one of the most popular beverages worldwide, and the effects of
tea consumption on PD risk have attracted much attention in recent years
[6–17],
as the tea components, such as flavonoids, caffeine, and theanine, have
been proven to be neuroprotective in animal models of PD. Many studies
have found that tea drinking can lower the risk of PD [6–10, 12–15], while this beneficial effect of tea is not observed in other reports [11, 16].
The purpose of the present study was to perform a meta-analysis to
provide a comprehensive conclusion on the association between tea
drinking and PD risk, which has important implications for the
prevention and treatment of this disease.
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