Memorize this so when you have a stroke you can point out what needs to be done. All because NO one in the whole stroke medical world is writing and distributing stroke protocols. You're screwed until we get some stroke leadership.
Fingolimod enhances the efficacy of delayed alteplase administration in acute ischemic stroke by promoting anterograde reperfusion and retrograde collateral flow
Annals of Neurology — Tian DC, et al. | October 10, 2018
In acute ischemic stroke patients in
a delayed time window, researchers tested the effectiveness of
co-administration of fingolimod with alteplase. Study participants
included those with an internal carotid artery or middle cerebral artery
proximal occlusion within 4.5-6 hours from symptom onset. The results
obtained from this prospective, randomized, open-label, blinded endpoint
clinical trial indicated that fingolimod may enhance the effectiveness
of alteplase administration in the 4.5- to 6-hour time window in those
with a proximal cerebral arterial occlusion and salvageable penumbral
tissue by promoting both anterograde reperfusion and retrograde
collateral flow. Researchers noted that study participants who received
fingolimod and alteplase showed a greater decline in the perfusion
lesion accompanied by suppressed infarct growth by 24 hours.
Read the full article on Annals of Neurology
No comments:
Post a Comment