Association between vitamin D status and cognitive impairment in acute ischemic stroke patients: a prospective cohort study

I see nothing here that suggests that this is being written up as a stroke protocol and distributed worldwide to all stroke hospitals and doctors. Isn't that the minimum needed to 'do no harm'? 

Is this just Vitamin D or D3? Inquiring minds want to know.  Does low vitamin D cause this problem or the underlying reason that initially caused the low levels the real problem? Have you actually identified the root cause?

Vitamin D3 Could Help Prevent, Repair Cardiovascular System Damage

The latest here:

Association between vitamin D status and cognitive impairment in acute ischemic stroke patients: a prospective cohort study

Authors Chen H, Liu Y, Huang G, Zhu J, Feng W, He J
Received 11 September 2018
Accepted for publication 18 November 2018
Published 10 December 2018 Volume 2018:13 Pages 2503—2509
DOI https://doi.org/10.2147/CIA.S187142
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Andrew Yee
Peer reviewer comments 3
Editor who approved publication: Dr Wu

Huijun Chen,^1,* Yuntao Liu,^1,* Guiqian Huang,^1,* Jie Zhu,² Wenqian Feng,² Jincai He<sup>1

1</sup>Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China; ²Department of Mental Health, Mental Health School, Wenzhou Medical University, Wenzhou 325000, China

*These authors contributed equally to this work

Objective: Previous studies found that low vitamin D levels were modestly associated with risk of stroke and poor functional outcome after stroke. In addition, vitamin D deficiency has been linked with cognitive decline. Our study aimed to explore the potential relationship between vitamin D levels in the short-term acute phase of ischemic stroke and cognitive impairment at 1 month.
Methods: In total, 354 ischemic stroke patients were consecutively enrolled in the study and received 1-month follow-up. The serum levels of vitamin D were measured within 24 hours after admission. Cognitive function was evaluated by the Mini-Mental State Examination (MMSE) at 1 month after acute ischemic stroke. Cognitive impairment was defined according to different education levels.
Results: According to MMSE scores, 114 participants (32.2%) had cognitive impairment at 1 month. Patients with vitamin D deficiency were more likely to have cognitive impairment than those with vitamin D insufficiency and vitamin D sufficiency (P<0.001). After adjusting for potential confounders in our Cox proportional hazards model, vitamin D deficiency was independently associated with the development of cognitive impairment in acute ischemic stroke patients.
Conclusion: Independent of established risk factors, vitamin D deficiency in the short-term phase of ischemic stroke was associated with a higher incidence of 1-month cognitive impairment.

Keywords: vitamin D, cognitive impairment, ischemic stroke, Mini-Mental State Examination

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