Effects of Voluntary Physical Rehabilitation on Neurogenesis In SVZ And Functional Recovery After Ischemic Stroke

So the advisors to this dissertation candidate should followup with human research testing this out. That is the minimum a competent university department should be doing. 

Effects of Voluntary Physical Rehabilitation on Neurogenesis In SVZ And Functional Recovery After Ischemic Stroke

 

Author InfoBalakrishnan, Anuranjani

ORCID® Identifier

http://orcid.org/0000-0002-4407-5165

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http://rave.ohiolink.edu/etdc/view?acc_num=wright1537186443944433

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Year and Degree

2018, Master of Science (MS), Wright State University, Microbiology and Immunology.

Abstract

Stroke is the leading cause of long-term disability and 87% of all strokes are due to ischemic strokes. In this current study, we examined whether voluntary physical rehabilitation can influence neurogenesis (measured by Doublecortin) in the subventricular zone and show improved motor functional recovery in 10-12 month female rats after ischemia. We saw a significant increase in the neurogenesis (measured by doublecortin) of all three regions (anterior, middle and posterior) of SVZ in the rehab animals compared to control group when using a two-way variance ANOVA test, although we were unable to see significant differences in paired t-tests of similar regions for control and rehab animals. The control animals showed a significant increase in contralateral functional recovery of 56% with rehab animals displaying a recovery of 23%. These findings suggest that the physical rehabilitation showed increased neurogenesis in the SVZ but did not translate to greater contralateral functional recovery.

Committee

Adrian M. Corbett, Ph.D. (Committee Chair)
Nancy J. Bigley, Ph.D. (Committee Member)
Debra Ann Mayes, Ph.D. (Committee Member)

Pages

88 p.

Subject Headings

Immunology; Neurobiology; Neurosciences; Physiology; Rehabilitation

Keywords

neurogenesis; doublecortin; rehabilitation; ischemic stroke; ipsilateral recovery; contralateral recovery; Montoya Staircase

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wright1537186443944433

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Copyright Info© 2018, some rights reserved. Effects of Voluntary Physical Rehabilitation on Neurogenesis In SVZ And Functional Recovery After Ischemic Stroke by Anuranjani Balakrishnan is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. Based on a work at etd.ohiolink.edu.
This open access ETD is published by Wright State University and OhioLINK.