The role of neurogenesis in neurorepair after stroke

Where the fuck is the public writeup on this so the 10 million yearly stroke survivors  can use this to get recovered? Or do you not care about helping survivors?  Hide information in a research journal? 

Laziness? Incompetence? Or just don't care? No leadership? No strategy? Not my job?

The role of neurogenesis in neurorepair after stroke

Marques BL¹, Carvalho GA¹, Freitas EMM¹, Chiareli R¹, Barbosa TG¹, Di Araújo AGP¹, Nogueira YL¹, Ribeiro RI¹, Parreira RC¹, Vieira MS², Resende RR², Gomez RS³, Oliveira-Lima OC¹, Pinto MCX⁴.

Author information

Abstract

Stroke consists of an abrupt reduction of cerebral blood flow resulting in hypoxia that triggers an excitotoxicity, oxidative stress, and neuroinflammation. After the ischemic process, neural precursor cells present in the subventricular zone of the lateral ventricle and subgranular zone of the dentate gyrus proliferate and migrate towards the lesion, contributing to the brain repair. The neurogenesis is induced by signal transduction pathways, growth factors, attractive factors for neuroblasts, transcription factors, pro and anti-inflammatory mediators and specific neurotransmissions. However, this endogenous neurogenesis occurs slowly and does not allow a complete restoration of brain function. Despite that, understanding the mechanisms of neurogenesis could improve the therapeutic strategies for brain repair. This review presents the current knowledge about brain repair process after stroke and the perspectives regarding the development of promising therapies that aim to improve neurogenesis and its potential to form new neural networks.

KEYWORDS:

Stroke; brain ischemia; brain repair; neurogenesis

PMID:

30550812

DOI:

10.1016/j.semcdb.2018.12.003