Wednesday, February 13, 2019

A Mendelian Randomization Approach for Assessing the Relationship Between Physical Activity and Depression

So instead of having to address poststroke depression(33% chance), your doctor could get you recovered enough to do the exercise necessary to prevent depression. But I bet your doctors will not address it that way since they have NO CLUE on what therapies actually work. They write prescriptions to the therapists saying E.T.(Evaluate and Treat). That means they know nothing about stroke rehab and are hoping their therapists do. Which is probably why only 10% of patients get to full recovery.

A Mendelian Randomization Approach for Assessing the Relationship Between Physical Activity and Depression

JAMA Psychiatry. Published online January 23, 2019. doi:10.1001/jamapsychiatry.2018.3870
There is a large and growing need to better manage the burden of major depression. Antidepressants are not universally effective, and many patients undergo a trial-and-error process to find the right regimen. Psychological therapies are about equally effective and can be expensive and difficult to access. Reducing the number of individuals who develop depression would be ideal, but identifying robust protective factors that are modifiable has proven challenging. Physical exercise has emerged as a key opportunity. In large cross-sectional studies,1 individuals who exercise report significantly better mental health. In large prospective cohort studies,2 individuals who exercise are less likely to develop depression. In randomized clinical trials,3 people who were assigned to exercise groups had greater depressive symptom reduction than those who were not. Individuals with depression who are taking antidepressants and exercise more are significantly more likely to recover than those who exercise less.4 Case closed, perhaps?

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