This means your doctor has to get you recovered enough to be able to exercise enough not to get obese/overweight. You don't want brain atrophy on top of your stroke. I gained 35 lbs. and went into the overweight category because I wasn't able to return to my normal physical activities; canoeing, xc skiing, biking, hiking.
Brain structure and obesity
Raji CA1, Ho AJ, Parikshak NN, Becker JT, Lopez OL, Kuller LH, Hua X, Leow AD, Toga AW, Thompson PM.
Abstract
Obesity
is associated with increased risk for cardiovascular health problems
including diabetes, hypertension, and stroke. These cardiovascular
afflictions increase risk for cognitive decline and dementia, but it is
unknown whether these factors, specifically obesity and Type II
diabetes, are associated with specific patterns of brain atrophy. We
used tensor-based morphometry (TBM) to examine gray matter (GM) and
white matter (WM) volume differences in 94 elderly subjects who remained
cognitively normal for at least 5 years after their scan. Bivariate
analyses with corrections for multiple comparisons strongly linked body
mass index (BMI), fasting plasma insulin (FPI) levels, and Type II
Diabetes Mellitus (DM2) with atrophy in frontal, temporal, and
subcortical brain regions. A multiple regression model, also correcting
for multiple comparisons, revealed that BMI was still negatively
correlated with brain atrophy (FDR <5%), while DM2 and FPI were no
longer associated with any volume differences. In an Analysis of
Covariance (ANCOVA) model controlling for age, gender, and race, obese
subjects with a high BMI (BMI > 30) showed atrophy in the frontal
lobes, anterior cingulate gyrus, hippocampus, and thalamus compared with
individuals with a normal BMI (18.5-25). Overweight subjects (BMI:
25-30) had atrophy in the basal ganglia and corona radiata of the WM.
Overall brain volume did not differ between overweight and obese
persons. Higher BMI was associated with lower brain volumes in
overweight and obese elderly subjects. Obesity is therefore associated
with detectable brain volume deficits in cognitively normal elderly
subjects.
2009 Wiley-Liss, Inc.
- PMID:
- 19662657
- PMCID:
- PMC2826530
- DOI:
- 10.1002/hbm.20870
- [Indexed for MEDLINE]
No comments:
Post a Comment