While this one failed, this type of research is EXACTLY what we need to know. Which circulating micronutients will prevent dementia and what ARE THE EXACTS AMOUNTS TO CONSUME to get to those levels. Guidelines are worthless, fire anyone who suggests guidelines, we can't have such lazy people stay in the stroke field.
Circulating antioxidants and Alzheimer disease prevention: A Mendelian randomization study
American Journal of Clinical Nutrition — Williams DM, et al. | February 04, 2019
In this study, researchers
determined if long-term circulating antioxidant exposure plays a role in
Alzheimer disease (AD) etiology by testing the premise that AD risk
would be lower in individuals with lifelong, genetically predicted
increases in concentrations of four circulating antioxidants that are
modifiable by diet. To that end, they performed two-sample Mendelian
randomization analyses, and investigated single-nucleotide polymorphisms
(SNPs) that determine variation in circulating ascorbate (vitamin C),
β-carotene, retinol (vitamin A), and urate by analyzing published
genetic-association studies. Using data of a genome-wide association
study of late-onset AD cases and controls (n=17,008 and 37,154,
respectively), they extracted statistics for genotype associations with
AD risk for each set of SNP data. According to findings, no lowered risk
of AD was observed in association with higher exposure to ascorbate,
β-carotene, retinol, or urate. Replication Mendelian randomization
studies could assess this further, providing larger AD case-control
samples and, ideally, using additional variants to instrument each
exposure.
Read the full article on American Journal of Clinical Nutrition
No comments:
Post a Comment