Abstract
The
purpose of this study is to assess the effect of vitamin D replacement
on cognitive function in older adults. A total of 560 patients who
underwent comprehensive geriatric assessment including Global cognitive
assessment, Basic Activities of Daily Living (BADL), and Instrumental
Activities of Daily Living (IADL) twice in 6-month period were
retrospectively reviewed. Oral cholecalciferol was replaced to patients
with vitamin D deficiency routinely. In baseline cognitive scores,
BADL-IADL scores were lower in the severe deficiency group than in the
deficiency and adequate groups (P < .05). With regard to the
relation between changes in cognitive functions, BADL-IADL scores on the
6-month versus baseline, no difference was determined in patients with
and without dementia (P > .05). Vitamin D replacement may not
improve cognitive performance in older adults, even if vitamin D is
raised to adequate level, suggesting that longer term replacement
therapy may be needed to improve cognitive function.
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