Hell, I had high levels of vigorous physical activity and had the cardiovascular fitness of an athlete and still had a stroke.  Good conscience laundering but not really that helpful. I'll live some 40 years past my stroke which means I'll have lived with cardivascular disease 4/9s of my life(44%).

039 - Low Levels of Moderate to Vigorous Physical Activity is Associated With Fewer Years Lived Free of Cardiovascular Disease: The Cardiovascular Lifetime Risk Pooling Project

Session 10 - Physical Activity

039 - Low Levels of Moderate to Vigorous Physical Activity is Associated With Fewer Years Lived Free of Cardiovascular Disease: The Cardiovascular Lifetime Risk Pooling Project

Itinerary

March 8, 2019, 10:56 AM - 11:07 AM

Galleria Ballroom - 3rd Floor

---

Authors

Amanda Paluch, Northwestern Univ, Chicago, IL; Hongyan Ning, Mercedes Carnethon, Northwestern Univ Feinberg Sch of Med, Chicago, IL; Kelley Pettee Gabriel, Univ of Texas Health Science Ctr at Houston, Sch of Public Health - Austin Campus, Austin, TX; Norrina Allen, Donald Lloyd-Jones, John Wilkins, Northwestern Univ Feinberg Sch of Med, Chicago, IL

Disclosures

 A. Paluch: None. H. Ning: None. M. Carnethon: None. K. Pettee Gabriel: None. N. Allen: None. D. Lloyd-Jones: None. J. Wilkins: None.

Abstract

Background: Quantifying the associations of moderate to vigorous intensity physical activity (MVPA) with years lived free of cardiovascular disease (CVD) allows for contextualization of the population burden and provides a metric for clinician-patient communication. We hypothesized that individuals with lower levels of MVPA during middle age will have fewer years lived free of CVD compared to those with higher levels.
Methods: A standardized z-score for MVPA was created based on participant-reported physical activity in 28,466 middle aged adults aged 40-59 years (43.6% women) in 6 U.S. prospective cohort studies. Z-scores were then categorized into quartiles for each cohort. Rates (person-years) of incident CVD and death were summed for participants up to age 95 years, or to the oldest age of observation. Irwin’s restricted mean was used to calculate years lived free from CVD and overall survival stratified by sex.
Results: Over 514,324 person-years of follow-up, 3,556 CVD events were observed. Whereas there was no difference in survival time among participants in the upper 3 quartiles, women in the lowest quartile vs. the next lowest quartile lived 3.2 fewer years and men lived 1.2 fewer years free of CVD. Survival after a CVD event was lower for women in the lowest MVPA quartile (mean±S.E: 0.07±0.32 years) compared to all other quartiles (Q2: 0.67±0.16 years to Q4: 0.96±0.16 years). Survival after CVD events was similar across all quartiles of MVPA for men, ranging from 1.1±0.05 to 1.4±0.05 years.
Conclusions: The benefits of physical activity extend multiple decades into older ages. Even modest levels of physical activity during middle age is associated with longer CVD-free survival, particularly among women.