WHOM is going to followup with stroke survivor testing to see if it helps stroke fatigue? I'm guessing no one since we have NO STROKE LEADERSHIP to contact to get simple stuff like this tested out. You're screwed until the existing fucking failures of stroke associations are destroyed and replaced by survivor run ones.
A randomised double-blind placebo-controlled feasibility trial of flavonoid-rich cocoa for fatigue in people with relapsing and remitting multiple sclerosis
Abstract
The impact of flavonoids on fatigue has not been investigated in relapsing and remitting multiple sclerosis (RRMS).
Objective To determine the feasibility and estimate the potential effect of flavonoid-rich cocoa on fatigue and fatigability in RRMS.
Methods
A randomised double-blind placebo-controlled feasibility study in
people recently diagnosed with RRMS and fatigue, throughout the Thames
Valley, UK (ISRCTN: 69897291). During a 6-week intervention participants
consumed a high or low flavonoid cocoa beverage daily. Fatigue and
fatigability were measured at three visits (weeks 0, 3 and 6).
Feasibility and fidelity were assessed through recruitment and
retention, adherence and a process evaluation.
Results
40 people with multiple sclerosis (10 men, 30 women, age 44±10 years)
were randomised and allocated to high (n=19) or low (n=21) flavonoid
groups and included in analysis. Missing data were <20% and adherence
to intervention of allocated individuals was >75%. There was a small
effect on fatigue (Neuro-QoL: effect size (ES) 0.04, 95% CI −0.40 to
0.48) and a moderate effect on fatigability (6 min walk test: ES 0.45,
95% CI −0.18 to 1.07). There were seven adverse events (four control,
three intervention), only one of which was possibly related and it was
resolved.
Conclusion A flavonoid beverage demonstrates the potential to improve fatigue and fatigability in RRMS.
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