So which of the 5 causes of the neuronal cascade of death in the first week is this addressing? Stop using neuroprotection, it doesn't conotate ANY SENSE OF URGENCY. If you don't know what you were addressing you were just shooting in the dark and got lucky. That is not a way to run stroke research. You follow and solve the stroke strategy of which we have none.
Novel neuroprotective tetramethylpyrazine analog T-006 promotes neurogenesis and neurological restoration in a rat model of stroke
doi: 10.1097/WNR.0000000000001256
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Neuronal death is among the deleterious pathological changes
that occur after cerebral ischemia and can lead to transient or
permanent neurological deficits. The tetramethylpyrazine analog
T-006 has been shown to be a multifunctional neuroprotective agent;
however, its neuroprotective effect and mechanism of action have not
been studied in ischemic stroke
model rats. This study investigated the neuroprotective effects of
T-006 in rat stroke model using a battery of behavioral and molecular
biological tests. Results indicated that T-006 treatment significantly
improved neurological function and behavior. Double immunofluorescence
staining showed that T-006 visibly improved the number of NeuN+/BrdU+, Nestin+/BrdU+, and DCX+/BrdU+ cells and induced neuronal regeneration. Western blot analyses indicated that T-006 upregulated neurogenesis-related protein expression of postsynaptic density protein 95, brain-derived neurotrophic factor, synaptophysin, and myelin basic protein. Collectively, these data suggest that T-006 stimulated neurogenesis in rats with middle cerebral artery occlusion and restored neurological functions.
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