Is Memory Decline Associated With Inflammatory Response?

Now is your doctor testing for this or just lazily using Occam's Razor to blame poor memory on stroke and do nothing about it? Ask your doctor that question, you need to know their competency. Does your doctor understand Occam's Razor and the bias it introduces?

 

Is Memory Decline Associated With Inflammatory Response?

Amber M. Tetlow, BA, Ross Andel, PhD, Frank J. Infurna, PhD

First Published November 21, 2017 Research Article

https://doi.org/10.1177/0898264317742809

Article information

Abstract

Objective: To examine whether changes in memory over a 10-year period could predict a change in C-reactive protein (CRP) levels.  
Method: A mixed model analysis was first conducted to obtain the estimates for change in memory over the 10-year period using data from the Health and Retirement Study. Then a multivariate regression to determine whether a change in episodic memory could predict subsequent CRP levels was conducted. Furthermore, a general linear model was conducted to determine differences in CRP levels among different rates of change in episodic memory.  
Results: Greater declines in episodic memory were associated with higher levels of subsequent CRP (Estimate = −0.32, SE = 0.12, β = −.03, p = .008). The general linear model revealed that those with greater memory declines were more likely to have higher levels of CRP, F = 26.50, p < .001. Discussion: These results highlight the notion that memory decline and inflammation may be intertwined, and we discuss various avenues that warrant further investigation.

Keywords cognitive function, cognitive status, biomarkers

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Article available in:

Vol 31, Issue 5, 2019

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