Melatonin in Alzheimer’s Disease: A Latent Endogenous Regulator of Neurogenesis to Mitigate Alzheimer’s Neuropathology

Lots of other research on melatonin for stroke so your doctor can add this to your protocols. Your doctor does have rehab protocols for you, doesn't she? But this is ultimately useless with no amounts or protocols on the use of it.

• melatonin (21 posts to February 2012)

Melatonin in Alzheimer’s Disease: A Latent Endogenous Regulator of Neurogenesis to Mitigate Alzheimer’s Neuropathology

• Authors
• Authors and affiliations

• Md. Farhad Hossain
• Md. Sahab Uddin
• G. M. Sala Uddin
• Dewan Md. Sumsuzzman
• Md. Siddiqul Islam
• George E. Barreto
• Bijo Mathew
• Ghulam Md Ashraf

• Md. Farhad Hossain
  • 1
• Md. Sahab Uddin
  • 2
  • 3
  Email authorView author's OrcID profile
• G. M. Sala Uddin
  • 2
• Dewan Md. Sumsuzzman
  • 4
• Md. Siddiqul Islam
  • 2
• George E. Barreto
  • 5
  • 6
• Bijo Mathew
  • 7
• Ghulam Md Ashraf
  • 8
  • 9
  Email authorView author's OrcID profile

1. 1.Department of Physical TherapyGraduate School of Inje UniversityGimhaeSouth Korea
2. 2.Department of PharmacySoutheast UniversityDhakaBangladesh
3. 3.Pharmakon Neuroscience Research NetworkDhakaBangladesh
4. 4.Department of Rehabilitation ScienceGraduate School of Inje UniversityGimhaeSouth Korea
5. 5.Departamento de Nutrición y Bioquímica, Facultad de CienciasPontificia Universidad JaverianaBogotá DCColombia
6. 6.Instituto de Ciencias BiomédicasUniversidad Autónoma de ChileSantiagoChile
7. 7.Division of Drug Design and Medicinal Chemistry Research Lab, Department of Pharmaceutical ChemistryAhalia School of PharmacyPalakkadIndia
8. 8.King Fahd Medical Research CenterKing Abdulaziz UniversityJeddahSaudi Arabia
9. 9.Department of Medical Laboratory Technology, Faculty of Applied Medical SciencesKing Abdulaziz UniversityJeddahSaudi Arabia

Article

First Online: 17 June 2019

Abstract

Melatonin, a pineal gland synthesized neurohormone is known as a multifunctioning pleiotropic agent which has a wide range of neuroprotective role in manifold age-related neurodegenerative disorders especially Alzheimer’s diseases (AD). AD is a devastating neurodegenerative disorder and common form of dementia which is defined by abnormal and excessive accumulation of several toxic peptides including amyloid β (Aβ) plaques and neurofibrillary tangles (NFTs). The Alzheimer’s dementia relates to atrophic changes in the brain resulting in loss of memory, cognitive dysfunction, and impairments of the synapses. Aging, circadian disruption, Aβ accumulation, and tau hyperphosphorylation are the utmost risk factor regarding AD pathology. To date, there is no exact treatment against AD progression. In this regard, melatonin plays a crucial role for the inhibition of circadian disruption by controlling clock genes and also attenuates Aβ accumulation and tau hyperphosphorylation by regulating glycogen synthase kinase-3 (GSK3) and cyclin-dependent kinase-5 (CDK5) signaling pathway. In this review, we highlight the possible mechanism of AD etiology and how melatonin influences neurogenesis by attenuating circadian disruption, Aβ formation, as well as tau hyperphosphorylation. Furthermore, we also find out and summarize the neuroprotective roles of melatonin by the blockage of Aβ production, Aβ oligomerization and fibrillation, tau hyperphosphorylation, synaptic dysfunction, oxidative stress, and neuronal death during AD progression.