I got absolutely nothing out of this. Did your doctor?
P75-T Adaptation of the motor system is associated with neuroplasticity
Author links open overlay panelShohrehKariminezhadabJariKarhucLauraSäisänenbJusaReijonenabMerviKönönenbdPetroJulkunenab
Background
Repetition suppression (RS), i.e., adaption of neural excitability in response to a repeated stimulus, manifests as a decrement in the amplitude of the motor evoked potentials (MEPs) following repeated transcranial magnetic stimulation (TMS) of the motor cortex. RS is associated with abnormal adaptation to external stimuli and may be indicative of neuroplastic capacity.
Objective
To investigate the association between RS and experimentally induced plasticity.
Methods
Fourteen
healthy subjects (7 males, aged 22–42 years) were studied with a RS
paradigm, which was applied prior and following (0 min, 10 min, and
20 min) paired associative stimulation (PAS). The RS paradigm,
consisting of twenty trains of four TMS pulses
with an inter-stimulus interval (ISI) of 1 s and an inter-train
interval (ITI) of 17 s, was applied to abductor pollicis brevis muscle ‘hotspot’. During PAS, median nerve stimulation was delivered 25 ms prior to TMS pulses given at 0.2 Hz for 15 min.
Results
A two-way repeated ANOVA identified 6 subjects with an interaction effect of RS and PAS (p < 0.05). Furthermore, the linear mixed model
revealed a significant effect of PAS on RS by time in the responders
((F10min = 4.965, p10min = 0.033) and (F20min = 7.519, p20min = 0.010)).
An independent samples t-test revealed that the resting motor threshold was significantly lower in responders than in non-responders (p = 0.05).
Conclusion
Our
results demonstrate that RS is facilitated in subjects showing the
interaction effect. This interaction might be mediated by the GABAergic
inhibitory system during activation of the negative thalamo-cortical
feedback loop due to the homeostatic plasticity.
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