Resveratrol
(3,4′,5-trihydroxystilbene) is a member of natural, plant-derived
chemicals known as polyphenols and is attracting increased attention due
to its diverse health benefits especially in case of cardiovascular
disease, cancer, diabetes and neurological problems. Despite impressive
gains in diagnosis and treatment, cardiovascular disease (CVD) remains a
serious clinical problem and threat to public health. Resveratrol
possesses potent antioxidant properties and has been shown to decrease
low-density lipoprotein–cholesterol oxidation and platelet aggregation.
This compound also possesses a range of additional cardioprotective and
vasoprotective properties including antiatherosclerotic and
vasorelaxation action. Resveratrol also has the capacity to interact
with multiple molecular targets, which involve diverse intracellular
pathways. Most well-known is the ability of resveratrol to activate
sirtuins, a class of NAD+-dependent deacetylase that affect
multiple transcription factors and other protein targets. Recently,
resveratrol was found to induce autophagy and regenerate myocardial
ischemic tissue treated with stem cells. Overall observation indicates
that resveratrol has a high therapeutic potentials for the treatment of
cardiovascular diseases.
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